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Rafael Fonseca MD

Rafael Fonseca MD

Chief Innovation Officer, Mayo Clinic; Getz Family Professor of Cancer, Professor of Medicine, Mayo Clinic School of Medicine, Phoenix, Arizona

Dr. Rafael Fonseca is the Getz Family Professor of Cancer, Professor of Medicine, Chief Innovation Officer, and a consultant in the Division of Hematology/Oncology at the Mayo Clinic in Arizona. He is a member of the Mayo Clinic Board of Governors and Board of Trustees.

Dr. Fonseca's practice has focused on the diagnosis and treatment of plasma cell disorders and leading the multiple myeloma team in its efforts to develop a better understanding of the disease and its impact on patients.

Throughout his training and career, Dr. Fonseca has received numerous awards and honors. Most notably, he is a Mayo Clinic Distinguished Investigator, the highest academic distinction given to investigators at his institution. Dr. Fonseca holds memberships and serves in positions for organizations such as the American Society of Clinical Oncology, American Society of Hematology, American Association for Cancer Research, and the International Myeloma Society.

Dr. Fonseca serves as reviewer and in editorial capacities for medical publications including Blood, The Lancet, Nature Medicine, Cancer Cell, Leukemia, and The New England Journal of Medicine, among others. He has given many national and international presentations as a visiting professor, and has authored numerous articles (over 300), book chapters, editorials, abstracts, and letters.

Disclosures

  • Consultant: AbbVie; Adaptive Biotechnologies; AMGEN; AstraZeneca; Bayer; Binding Site; BMS (Celgene); Millennium Takeda; Jansen; Juno;, Kite; Merck; Pfizer; Pharmacyclics; Regeneron; Sanofi.
  • Advisory Board: Adaptive Biotechnologies; Caris Life Sciences; ONCOtracker
  • Board of Directors: Antengene (for profit); AZBio (not for profit)
  • Patent for FISH in MM (~$2000/yr)

Recent Contributions to PracticeUpdate:

  1. Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
  2. Genomic Classification and Individualized Prognosis in Multiple Myeloma
  3. 2023 Top Story in Oncology: CAR T-Cell Therapy (Cilta-Cel) vs Standard of Care for Early Relapse Multiple Myeloma—The CARTITUDE-4 Study
  4. Ibrutinib and Venetoclax as Primary Therapy in Symptomatic Patients With Treatment-Naïve MYD88-Mutated Waldenström Macroglobulinemia
  5. Minimal Residual Disease Response–Adapted Therapy in Patients With Newly Diagnosed Multiple Myeloma
  6. Real-World Outcomes of ASCT as Initial Therapy in Patients With Multiple Myeloma
  7. ESMO 2023: Recommendations From Dr. Rafael Fonseca for General Oncology
  8. Addition of Daratumumab to Lenalidomide, Bortezomib, and Dexamethasone for Transplant-Eligible Patients With Newly Diagnosed Multiple Myeloma
  9. Mechanisms of Antigen Escape From BCMA- or GPRC5D-Targeted Immunotherapies in Multiple Myeloma
  10. Elranatamab for Relapsed or Refractory Multiple Myeloma

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