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Published in Oncology

Expert Opinion / Commentary · December 20, 2022

2022 Top Story in Oncology: The Pursuit of Minimal Residual Disease Negativity as the Main Goal of Multiple Myeloma Therapy

Rafael Fonseca MD

 

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Additional Info

  1. Landgren O, Devlin S, Boulad M, et al. Role of MRD Status in Relation to Clinical Outcomes in Newly Diagnosed Multiple Myeloma Patients: A Meta-Analysis. Bone Marrow Transplant. 2016;51(12):1565-1568.
  2. Munshi NC, Avet-Loiseau H, Rawstron AC, et al. Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis. JAMA Oncol. 2017;3(1):28-35.
  3. Munshi NC, Avet-Loiseau H, Anderson KC, et al. A Large Meta-Analysis Establishes the Role of MRD Negativity in Long-Term Survival Outcomes in Patients With Multiple Myeloma. Blood Adv. 2020;4(23):5988-5999.
  4. de Tute RM, Pawlyn C, Cairns DA, et al. Minimal Residual Disease After Autologous Stem-Cell Transplant for Patients With Myeloma: Prognostic Significance and the Impact of Lenalidomide Maintenance and Molecular Risk. J Clin Oncol. 2022;40(25):2889-2900.
  5. Paiva B, Puig N, Cedena MT, et al. Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma. J Clin Oncol. 2020;38(8):784-792.
  6. Paiva B, Manrique I, Dimopoulos MA, et al. MRD Dynamics During Maintenance for Improved Prognostication of 1280 Myeloma Patients in TOURMALINE-MM3 and -MM4 trials. Blood. 2022 Sep 21. Doi: 10.1182/blood.2022016782. Online ahead of print.
  7. Perrot A, Lauwers-Cances V, Corre J, et al. Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma. Blood. 2018;132(23):2456-2464.
  8. Moreau P, Attal M, Hulin C, et al. Bortezomib, Thalidomide, and Dexamethasone With or Without Daratumumab Before and After Autologous Stem-Cell Transplantation for Newly Diagnosed Multiple Myeloma (CASSIOPEIA): A Randomised, Open-Label, Phase 3 Study. Lancet. 2019;394(10192):29-38.

Disclosure statements are available on the authors' profiles:

Rafael Fonseca MD

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