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Published in Urology

Expert Opinion / Commentary · May 15, 2014

VUR in Children: Prophylactic Antibiotics Work

Craig Peters MD, FAAP, FACS

 

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Additional Info

  1. The RIVUR Trial Investigators. Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux [published online ahead of print May 4, 2014]. N Engl J Med. DOI: 10.1056/NEJMoa1401811.

  2. Normand IC, Smellie JM. Prolonged Maintenance Chemotherapy in the Management of Urinary Infection In Childhood. Br Med J. 1965;1(5441):1023-1026.

  3. Edwards D, Normand IC, Prescod N, Smellie JM. Disappearance of vesicoureteric reflux during long-term prophylaxis of urinary tract infection in children. Br Med J. 1977;2(6082):285-288.

  4. Jodal U, Smellie JM, Lax H, Hoyer PF. Ten-year results of randomized treatment of children with severe vesicoureteral reflux. Final report of the International Reflux Study in Children. Pediatr Nephrol. 2006;21(6):785-792.
  5. National Institute for Heath and Care Excellence (NICE). Urinary Tract Infection in Children (CG54). http://guidance.nice.org.uk/CG54. Issued August 2007. Accessed May 13, 2014.
  6. Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management, Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128(3):595-610.
  7. Craig JC, Simpson JM, Williams GJ, et al. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009;361(18):1748-1759.
  8. Brandström P, Esbjörner E, Herthelius M, et al. The Swedish reflux trial in children: I. Study design and study population characteristics. J Urol. 2010;184(1):274-279.
  9. Brandström P, Esbjörner E, Herthelius M, Swerkersson S, Jodal U, Hansson S. The Swedish reflux trial in children: III. Urinary tract infection pattern. J Urol. 2010;184(1):286-291.
  10. Brandström P, Nevéus T, Sixt R, Stokland E, Jodal U, Hansson S. The Swedish reflux trial in children: IV. Renal damage. J Urol. 2010;184(1):292-297.
  11. Peters CA, Skoog SJ, Arant BS Jr, et al. Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children. J Urol. 2010;184(3):1134-1144.

Disclosure statements are available on the authors' profiles:

Craig Peters MD, FAAP, FACS

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