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J. William McEvoy MB BCh BAO, MEd, MHS, PhD, FRCPI
J. William McEvoy MB BCh BAO, MEd, MHS, PhD, FRCPI Advisory Board
Anne Valente MD
Anne Marie Valente MD Advisory Board
Douglas Zipes MD
Douglas P. Zipes MD Editor-in-Chief
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Published in Cardiology

Expert Opinion / Commentary · August 29, 2016

The Pivotal Position of IL-6 in the Pathogenesis of Ischemic Heart Disease, and a Lot of New Questions

Peter Libby MD
Written by
Peter Libby MD

 

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Additional Info

  1. Hingorani AD and Casas JP. Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet. 2012;379(9822):1214-1224.
  2. Sarwar N, Butterworth AS, Freitag DF, et al. IL6R Genetics Consortium Emerging Risk Factors Collaboration. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012;379(9822):1205-1213.
  3. Kleveland O, Kunszt G, Bratlie M, et al. Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial [published online May 8, 2016]. Eur Heart J. DOI 1093/eurheartj/ehw171.
  4. Kinlay S, Schwartz GG, Olsson AG, et al. High-Dose Atorvastatin Enhances the Decline in Inflammatory Markers in Patients With Acute Coronary Syndromes in the MIRACL Study. Circulation. 2003;108(13):1560-1566.
  5. Morton AC, Rothman AM, Greenwood JP, et al. The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study. Eur Heart J. 2015;36(6):377-384.
  6. Libby P, Nahrendorf M, Swirski FK. Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease. J Am Coll Cardiol. 2016;67(9):1091-1103.

Disclosure statements are available on the authors' profiles:

Peter Libby MD

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