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Smoking Is an Independent Marker of Poor Prognosis in Cutaneous Melanoma
abstract
This abstract is available on the publisher's site.
Access this abstract nowPrevious studies have suggested that persistent tobacco smoking impairs survival in cutaneous melanoma, but the effects of smoking and other prognostic factors have not been described in detail. This study examined the association of smoking (persistent, former, or never) with melanoma-specific (MSS) and overall survival (OS) in patients with cutaneous melanoma treated in Southwest Finland during 2005 to 2019. Clinical characteristics were obtained from electronic health records for 1,980 patients. Smoking status was available for 1,359 patients. Patients were restaged according to the 8th edition of the tumour-node-metastasis (TNM) classification. Smoking remained an independent prognostic factor for inferior melanoma-specific survival regardless of age, sex, stage, and comorbidities. The hazard ratio of death from melanoma was 1.81 (1.27-2.58, p = 0.001) in persistent and 1.75 (1.28-2.40, p = 0.001) in former smokers compared with never smokers. In 351 stage IV patients, smoking was associated with increased melanoma-specific and overall mortality: median MSS 10.4 (6.5-14.3), 14.6 (9.1-20.1), and 14.9 (11.4-18.4) months, p = 0.01 and median OS 10.4 (6.5-14.3), 13.9 (8.6-19.2), and 14.9 (11.7-18.1) months, p = 0.01 in persistent, former, and never smokers, respectively. In conclusion, since smoking represents an independent modifiable poor prognostic factor in patients with cutaneous melanoma, smoking habits should be proactively asked about by healthcare professionals, in order to support smoking cessation.
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Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma
Acta Derm Venereol 2023 Feb 07;103(2023)adv00860, K Mattila, H Vihinen, A Karlsson, H Minn, P Vihinen, E HeerväFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
As dermatologists we preach "sunscreens" and "look for changing lesions" as ways to prevent skin cancers and identify malignant lesions sooner. But, encouraging people to quit smoking cigarettes is associated with much more risk reduction in terms of morbidity and mortality on a population basis. This study on melanoma survival risk is just one more reason to pay attention to this detail.
I find I'm pretty good about engaging with patients on the topic, as I believe there are data to support "each time you quit, you have a higher chance of quitting for good." If I'm wrong, then this is one area where I'm not going to worry about a randomized trial...changing habits, especially when there is a chemical dependency associated, can be very difficult, and I'm going with motivation wherever I can find it. Here are my usual lines, not always in this order, in case you want to adopt some version of these to your practice:
So when are you going to quit smoking?
if the answer is "never," then hopefully they really enjoy it.
if the answer is I've tried, then I share my "data" about the benefits of trying again.
I make the question light and say things like, "why don't we pick a date to quit?" and "I love April FOOLS day, because we DO know it's a bit foolish to smoke" (although, any easy-to-remember date coming up like Memorial Day, Labor Day, a birthday, etc would work as well).
if they tell me they need help, I provide whatever they need, although I don't generally prescribe medications except for those patients who I know quite well and use me (albeit inappropriately) as the only physician they see. I am a big believer in directing all patients to a primary care provider who can coordinate access for programs and medications for any motivated patient.
Here's the great news....since I've taken a lighter approach to it, every year I get several people who come back and thank me....somehow I was the tipping point of conversation. It only takes a few seconds, and, if I'm rebuffed, I let it go and move on.