Welcome to PracticeUpdate! We hope you are enjoying access to a selection of our top-read and most recent articles. Please register today for a free account and gain full access to all of our expert-selected content.
Already Have An Account? Log in Now
Outcomes of Time-Restricted Eating in Adults With Metabolic Syndrome
TAKE-HOME MESSAGE
- This study assessed the outcomes of time-restricted eating (TRE) combined with standard-of-care treatments in adults with metabolic syndrome. TRE combined with standard-of-care treatments led to greater improvements in HbA1c levels and various cardiometabolic health markers than standard-of-care alone. The participants in the TRE group experienced significant reductions in body weight, body fat percentage, and cholesterol levels. Additionally, the participants in the TRE group reduced their daily caloric intake by an average of 350 kcal, mainly owing to reduced carbohydrate and fat intake, with no substantial reduction in dietary protein. The participants in the TRE group adhered to their eating window more than 85% of the time throughout the intervention.
- TRE represents an effective lifestyle strategy that can be utilized with standard pharmacotherapies and nutritional counseling to actively enhance glycemic regulation and various aspects of cardiometabolic health.
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
OBJECTIVE
To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.
DESIGN
Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).
SETTING
Clinical research institute.
PARTICIPANTS
Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A1c (HbA1c; pharmacotherapy allowed).
INTERVENTION
Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.
MEASUREMENTS
Primary outcomes were HbA1c, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.
RESULTS
108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m2; eating window of 14.19 hours). Compared with SOC, TRE improved HbA1c by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.
LIMITATION
Short duration, self-reported diet, potential for multiple elements affecting outcomes.
CONCLUSION
Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.
PRIMARY FUNDING SOURCE
National Institutes of Health.
Additional Info
Disclosure statements are available on the authors' profiles:
Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial
Ann. Intern. Med 2024 Oct 01;[EPub Ahead of Print], ENC Manoogian, MJ Wilkinson, M O'Neal, K Laing, J Nguyen, D Van, A Rosander, A Pazargadi, NR Gutierrez, JG Fleischer, S Golshan, S Panda, PR TaubFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.