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Published in Metastatic Breast Cancer

Expert Opinion / Cases · May 29, 2017

Neo-Adjuvant Chemotherapy in Elderly Female With Early Stage Triple Negative Breast Cancer

Sameer Nasir MD

 

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  • HAMDI Djelloul

    Jun 02, 2017

    4 EC followed by 12 weekly paclitaxel seems to be reasonable for this patient with a high grade tumour

  • Vijay Devanhalli

    Jun 04, 2017

    Tumour size 2.9cms is T2. What is the indication for a PET-CT scan ?

  • mauricio chveid

    Jun 05, 2017

    I would never begin this case with Neo adj. Simply localized surgery followed by RTX. There is no any evidence of good results in term of FS or OS in cases like this. On contrary, the side effects are tremendous in this age, sometimes with very bad outcome.

  • N Cul

    Jun 08, 2017

    Comorbid conditions?
Life expectancy? Patient wishes? Family history?

  • Dragutin Donat

    Jun 10, 2017

    I agree with N Cul

  • João Campos

    Jul 12, 2017

    First surgery and after chemo with EC and taxane

  • Bharat Bhosale

    Jul 25, 2017

    agree with Surgery followed by adjuvant approach
if final histology Node negative TNBC reference TC x 6 cycles or AC x 6 cycles

  • ibra algo

    Jul 26, 2017

    18F–FDG-PET/CT revealed distant metastases in 14% OF stage IIb disease see Eur J Nucl Med Mol Imaging (2017) 44:1420–1427

  • Kavi Capildeo

    Jul 26, 2017

    In the non-trial setting in the community, neoadjuvant chemotherapy is not a common approach for a 2.9 cm breast cancer as most would be amenable to initial lumpectomy + axillary staging (SLNB if clinically negative axilla). Is this a borderline case for lumpectomy based on breast size/ tumor location? Would discuss with surgeon-- ideally in tumor board setting.
If neoadjuvant chemo were agreed upon and was not precluded by cardiac or other comorbidities, I would consider weekly paclitaxel x 12 followed by AC x 4 (would also consider this as adjuvant chemo if surgery done first). Radiotherapy would be indicated if breast conserving surgery is done.

  • Helidon Nina

    Jul 30, 2017

    If there are no comorbidity condition: Lumpectomy and LNSB, if the patient prefer conservative surgery following by radiotherapy. After final result of pathological finding, consulting with board tumor staff

  • N'DA MARCELIN HOMIAN

    Aug 12, 2017

    Lumpectomy+axillary node dissection aiming at free margins, adjuvant chemotherapy ( 3EC+12 weekly paclitaxel) based on pathologic findings, then radiation therapy.

  • Feb 02, 2025

    Pending Moderator approval.
    Delete

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