Methotrexate Improves Pain and Inflammation in Patients With Arthralgia But Does Not Prevent Progression to Clinical Arthritis
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Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial
Lancet 2022 Jul 23;400(10348)283-294, DI Krijbolder, M Verstappen, BT van Dijk, YJ Dakkak, LE Burgers, AC Boer, YJ Park, ME de Witt-Luth, K Visser, MR Kok, ETH Molenaar, PHP de Jong, S Böhringer, TWJ Huizinga, CF Allaart, E Niemantsverdriet, AHM van der Helm-van MilFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.