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Renal Cell Carcinoma
Center of Excellence
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In an effort to better serve our users, we have streamlined our content offering. As a result, we no longer publish new content or update existing content in Renal Cell Carcinoma. Visit the 'Content & Subscriptions' tab of your Settings page at any time to update your Dashboard or Newsletter Subscription preferences to continue to see news and information that interests you most.
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Amougou Boris
Nov 05, 2016
There is some risk to increase the volume of metastatic mass (spine lytic lesion and lung nodule) using sutent. In my point of view its was a good case to purpose him to agree in a trial who assess the impact of usual targeted therapy in non clear cell metastatic renal carcinoma.
Laszlo Torday
Dec 06, 2016
I would be very concerned about the concomittant tretament of this patient with denosumab and sunitinib. Anti-VEGF TKI treatment dramatically increase the freqency of the BRONJ (bisphosphonate related osteonecrosis of the jaw) if the patient is receiving e.g. zoledronic acid. ONJ also a well known side effect of denosumab and denosumab is more potent bone targeting agent than zoledronic acid. There are several reports out there about the interaction of sunitinib and denosumab, and the picture is not worry free... I would also use sunitinib, but with a less potent bisphosphonate like clodronate... And, if applicable, palliatívie radiotherapy to metastatic bone lesions...
zafor masud
Jan 17, 2017
I agree to start with Xgeva and Sutent as recommended at this stage for him with the hope of better control of disease.
LCH3YSSWMI40065 LCH3YSSWMI40065
Jan 19, 2017
Yes I agree
Dec 18, 2024
Pending Moderator approval.
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Amougou Boris
Nov 05, 2016
Laszlo Torday
Dec 06, 2016
zafor masud
Jan 17, 2017
LCH3YSSWMI40065 LCH3YSSWMI40065
Jan 19, 2017
Dec 18, 2024
Pending Moderator approval.