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Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant?
abstract
This abstract is available on the publisher's site.
Access this abstract nowObesity has adverse effects on nearly every organ system. Weight loss is the primary treatment goal of obesity management because it improves or resolves obesity-related complications. The therapeutic effect of weight loss is proportional to the relative decrease in body weight. For example, 5% to 10% weight loss in people with type 2 diabetes improves glycemic control, whereas 15% to 25% weight loss can achieve diabetes remission. The ability to achieve a large amount of weight loss has typically been limited to bariatric surgery. However, the advent of glucagon-like peptide-1 (GLP-1)–based antiobesity medications has established a new era in the pharmacological therapy of obesity, with mean weight loss of 15% to 25% at 1 to 1.5 years.
Additional Info
Is Weight Loss-Induced Muscle Mass Loss Clinically Relevant?
JAMA 2024 Jun 03;[EPub Ahead of Print], C Conte, KD Hall, S KleinFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.