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Expert Opinion / Commentary · January 21, 2015

Impact of Androgen Deprivation Therapy in Intermediate-Risk Prostate Cancer

Anthony D’Amico MD, PhD

 

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Additional Info

  1. Mohler JL, Kantoff PW, Armstrong AJ, et al. Prostate cancer, version 1.2014. J Natl Compr Canc Netw. 2013;11(12):1471-1479.
  2. Mitchell JA, Cooperberg MR, Elkin EP, et al. Ability of 2 pretreatment risk assessment methods to predict prostate cancer recurrence after radical prostatectomy: data from CaPSURE. J Urol. 2005;173(4):1126-1131.
  3. Zumsteg ZS, Spratt DE, Pei I, et al. A new risk classification system for therapeutic decision making with intermediate-risk prostate cancer patients undergoing dose-escalated external-beam radiation therapy. Eur Urol. 2013;64(6):895-902.
  4. Castle KO, Hoffman KE, Levy LB, et al. Is androgen deprivation therapy necessary in all intermediate-risk prostate cancer patients treated in the dose escalation era? Int J Radiat Oncol Biol Phys. 2013;85(3):693-699.
  5. Keane FK, Chen M-H, Zhang D, et al. The likelihood of death from prostate cancer in men with favorable or unfavorable intermediate-risk disease. Cancer. 2014;120(12):1787-1793.
  6. Jones CU, Hunt D, McGowan DG, et al. Radiotherapy and short-term androgen deprivation for localized prostate cancer. N Engl J Med. 2011;365(2):107-118.
  7. Pisansky TM, Hunt D, Gomella LG, et al. Duration of androgen suppression before radiotherapy for localized prostate cancer –Radiation Therapy Oncology Group Randomized Clinical Trial 9910 [published online December 22, 2014]. J Clin Oncol. doi: 10.1200/JCO.2014.58.0662.

  8. Zapatero A, Guerrero A, Maldonado, et al. Randomized phase 3 trial of adjuvant androgen deprivation in combination with high dose conformal radiation therapy in intermediate- and high-risk prostate cancer. Int J Radiat Oncol. 2014;90(1 Suppl):S1.

  9. Radiation Therapy Oncology Group. Radiation therapy with or without androgen-deprivation therapy in treating patients with prostate cancer. ClinicalTrials.gov Website. Available at: https://clinicaltrials.gov/ct2/show/NCT00936390. Updated July 21, 2014. Accessed January 4, 2015.

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