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Impact of Allosteric PI3Kα Inhibition on On-Target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
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Cancer Discovery
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
Cancer Discov 2024 Feb 08;14(2)227-239, A Varkaris, F Fece de la Cruz, EE Martin, BL Norden, N Chevalier, AM Kehlmann, I Leshchiner, H Barnes, S Ehnstrom, AM Stavridi, X Yuan, JS Kim, H Ellis, A Papatheodoridi, H Gunaydin, BP Danysh, L Parida, I Sanidas, Y Ji, K Lau, GM Wulf, A Bardia, LM Spring, SJ Isakoff, JK Lennerz, K Del Vecchio, L Pierce, E Pazolli, G Getz, RB Corcoran, D JuricFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.