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Clinical Presentation, Diagnosis, and Management of Drug Reaction With Eosinophilia and Systemic Symptoms
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- Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed type IV hypersensitivity reaction. This review summarizes the clinical presentation, diagnosis, pathogenesis, treatment options, and long-term sequelae of DRESS. It is the most prevalent severe cutaneous adverse reaction and requires prompt drug discontinuation, potential treatment with systemic glucocorticoids, and multidisciplinary follow-up owing to its potential for relapses and long-term autoimmune complications.
- This comprehensive review highlights the clinical characteristics of DRESS and may aid clinicians in the management of patients with this condition.
abstract
This abstract is available on the publisher's site.
Access this abstract nowDrug reaction with eosinophilia and systemic symptoms (DRESS) is a T-cell–mediated severe cutaneous adverse reaction characterized by rash, fever, internal organ involvement, and systemic manifestations after prolonged exposure to a medication. DRESS is also known as drug-induced hypersensitivity syndrome and was formerly known as anticonvulsant hypersensitivity syndrome, given its connection to such drugs (details about disease terminology are provided in Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org).
Additional Info
Drug Reaction with Eosinophilia and Systemic Symptoms
N. Engl. J. Med 2024 Dec 12;391(23)2242-2254, D Kroshinsky, ARG Cardones, KG BlumenthalFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.