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Published in Brain Cancer

Expert Opinion / Cases · August 02, 2021

60 Yr Old Male Diagnosed With Right Temporal Glioblastoma

Saurabh Didwania

 

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  • srinivas rao

    Aug 06, 2021

    Mri brain with contrast and perfusion

  • Amir Azadi

    Aug 06, 2021

    NGS of the tumor?

  • Saurabh Didwania

    Aug 06, 2021

    Ok We will go for MRI within 7 days .
Sir is it 100 percent sure that recurrence will occur or there is any chance that recurrence will not occur again after GTR and radiation .

  • Minesh Mehta

    Aug 27, 2021

    The role of temozolomide in unmethylated GBM remains a controversial issue; however, this patient has already had 4 cycles, and I would complete an additional 2 cycles to complete 6.  Going by level 1 data, one could still potentially consider adding TTField therapy, as there is a randomized trial demonstrating survival advantage, irrespective of methylation status.  NGS has a small probability of yielding an actionable mutation, but if possible, could be considered.  Recurrence is most likely at some point down the line, although all of us have the very few exceptional patients that have become long-term survivors, and therefore, in someone who has had a gross total resection, I would never take hope away.

  • Saurabh Didwania

    Nov 12, 2021

    Dear All 
Thanks for the suggestions .Now the patient has completed 7 cycles of temozolomide .
Physically and mentally fit after 11 months of surgery 
Any other suggestions.

  • Saurabh Didwania

    Mar 21, 2022

    11 cycles of temozolomide completed no physical imbalance in memory or in walking eating and sleeping .dr is saying to go for mri after 12 cycles .pls suggest

  • srinivas rao

    Mar 22, 2022

    I agree with your doctor

  • Mayer Gorbaty

    Mar 22, 2022

    I have a question for the group.  What is the optimal # of cycles for adjuvant temozolomde? Is it 6? 12?  indefinitely until progression?

  • srinivas rao

    Mar 22, 2022

    This question is infact quite interesting.There is no definite answer for this.Usually i give upto 12 cycles if the patient is tolerating well symptomatically,lab wise n imaging wise.But if you see the literature there are few anecdotal papers where TMZ was given for 101 cycles.So it is your Oncologist who has to decide

  • Saurabh Didwania

    Apr 15, 2022

    12 cycles of temozolomide completed no physical imbalance in memory or in walking eating and sleeping .when to go for MRI or to give any other medication  .pls suggest

  • Saurabh Didwania

    Apr 27, 2022

    Any other treatment suggestions by any one .What treatment we can continue as 12 cycles of temozolomide completed  so that recurrence can be controlled

  • Saurabh Didwania

    Jul 03, 2022

    17 months completed without any symptoms .No MRI done till now after surgery .
Is MRI suggested ?
No complains no symptoms .
Walking +speech + memory all good .

  • Saurabh Didwania

    May 03, 2024

    3 years 4 months gone after surgery of GBM .Every 6 month MRI done .no residual part shown in MRI .no new development ..
Any other test required to check ?

  • Feb 01, 2025

    Pending Moderator approval.
    Delete

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