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Expert Opinion / Commentary · December 08, 2022

2022 Top Story in Brain Cancer: Proton Craniospinal Irradiation for Leptomeningeal Disease

Rupesh Kotecha MD

 

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  1. Lamba N, Wen PY, Aizer AA. Epidemiology of Brain Metastases and Leptomeningeal Disease. Neuro Oncol. 2021;23(9):1447-1456.
  2. Palmisciano P, Watanabe G, Conching A, et al. Intrathecal therapy for the management of leptomeningeal metastatic disease: a scoping review of the current literature and ongoing clinical trials. J Neurooncol. 2022;160(1):79-100.
  3. Le Rhun E, Ruda R, Devos P, et al. Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe. J Neurooncol. 2017;133(2):419-427.
  4. Harada H, Mitsuya K, Asakura H, et al. Cranio-Spinal Irradiation for Leptomeningeal Carcinomatosis: A Pilot Study. Int J Radiat Oncol Biol Phys. 2014;90(1):S310.
  5. Devecka M, Duma MN, Wilkens JJ, et al. Craniospinal irradiation(CSI) in patients with leptomeningeal metastases: risk-benefit-profile and development of a prognostic score for decision making in the palliative setting. BMC Cancer. 2020;20(1):501.
  6. Le Rhun E, Weller M, Brandsma D, et al. EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours. Ann Oncol. 2017;28(suppl_4):iv84-iv99.
  7. Brown AP, Barney CL, Grosshans DR, et al. Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. Int J Radiat Oncol Biol Phys. 2013;86(2):277-284.
  8. Yang TJ, Wijetunga NA, Yamada J, et al. Clinical trial of proton craniospinal irradiation for leptomeningeal metastases. Neuro Oncol. 2021;23(1):134-143.
  9. Yang JT, Wijetunga NA, Pentsova E, et al. Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. J Clin Oncol. 2022 Jul 8. Doi: 10.1200/JCO.22.01148. Online ahead of print.

Disclosure statements are available on the authors' profiles:

Rupesh Kotecha MD

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