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Geoffrey Connors MD, FACP
Geoffrey R. Connors MD, FACP Associate Editor
Shyoko Honiden MD, MSc
Shyoko Honiden MD, MSc Editor-in-Chief
Virginia Brady MD
Virginia A. Brady MD Associate Editor
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Published in Respiratory Medicine

Expert Opinion / Commentary · December 14, 2023

2023 Top Story in Respiratory Medicine: Steroid Use in Community-Acquired Pneumonia

Virginia Brady MD

 

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Additional Info

  1. Kyu HH, Vongpradith A, Sirota SB, et al. Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019. Lancet Infect Dis. 2022;22(11):1626-1647.
  2. Ramirez JA, Wiemken TL, Peyrani P, et al. Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality. Clin Infect Dis. 2017;65(11):1806-1812.
  3. Liapikou A, Ferrer M, Polverino E, et al. Severe Community‐Acquired Pneumonia: Validation of the Infectious Diseases Society of America/American Thoracic Society Guidelines to Predict an Intensive Care Unit Admission. Clin Infect Dis. 2009;48(4):377-385.
  4. Cavallazzi R, Wiemken T, Arnold FW, et al. Outcomes in patients with community-acquired pneumonia admitted to the intensive care unit. Respir Med. 2015;109(6):743-750.
  5. Kochanek KD, Murphy SL, Xu J, Arias E. Natl Vital Stat Rep. Deaths: Final Data for 2020. 2023 Sep;72(10):1-92.
  6. Snijders D, Daniels JMA, De Graaff CS, et al. Efficacy of Corticosteroids in Community-acquired Pneumonia: A Randomized Double-Blinded Clinical Trial. Am J Respir Crit Care Med. 2010;181(9):975-982.
  7. Meijvis SC, Hardeman H, Remmelts HH, et al. Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011;377(9782):2023-2030.
  8. Fernández-Serrano S, Dorca J, Garcia-Vidal C, et al. Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial. Crit Care. 2011;15(2):R96.
  9. Blum CA, Nigro N, Briel M, et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2015;385(9977):1511-1518.
  10. Torres A, Sibila O, Ferrer M, et al. Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response: A Randomized Clinical Trial. JAMA. 2015;313(7):677-686.
  11. Wittermans E, Vestjens SMT, Spoorenberg SMC, et al. Adjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: a randomised clinical trial. Eur Respir J. 2021;58(2):2002535.
  12. Confalonieri M, Urbino R, Potena A, et al. Hydrocortisone Infusion for Severe Community-acquired Pneumonia: A Preliminary Randomized Study. Am J Respir Crit Care Med. 2005;171(3):242-248.
  13. Chen Y, Li K, Pu H, Wu T. Corticosteroids for pneumonia. Cochrane Database Syst Rev. 2011;(3): CD007720.
  14. Briel M, Spoorenberg SMC, Snijders D, et al. Corticosteroids in Patients Hospitalized With Community-Acquired Pneumonia: Systematic Review and Individual Patient Data Metaanalysis. Clin Infect Dis. 2018;66(3):346-354.
  15. Stern A, Skalsky K, Avni T, et al. Corticosteroids for pneumonia. Cochrane Acute Respiratory Infections Group, ed. Cochrane Database Syst Rev. 2017;2017(12):CD007720.
  16. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67.
  17. The Corticosteroid Guideline Task Force of SCCM and ESICM, Pastores SM, Annane D, Rochwerg B. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med. 2018;44(4):474-477.
  18. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941.
  19. Meduri GU, Shih MC, Bridges L, et al. Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia. Intensive Care Med. 2022;48(8):1009-1023.
  20. Bergmann F, Pracher L, Sawodny R, et al. Efficacy and Safety of Corticosteroid Therapy for Community-Acquired Pneumonia: A Meta-Analysis and Meta-Regression of Randomized, Controlled Trials. Clin Infect Dis. 2023 Oct 25: doi: 10.1093/cid/ciad496. Online ahead of print.

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