Multimodal Treatment Effective for Barrett's Esophagus–Related Neoplasia
abstract
This abstract is available on the publisher's site.
Access this abstract nowOBJECTIVE
Photodynamic therapy (PDT) was used as therapy for early neoplasia associated with Barrett's oesophagus (BE). This is 5-year follow-up of patients enrolled into randomised controlled trial of 5-aminolaevulinic acid (ALA) vs. Photofrin PDT.
METHODS
Biopsies were taken from original Barrett's segment during endoscopic follow up using Seattle protocol. Endoscopic mucosal resection (EMR) ± radiofrequency ablation (RFA) was preferred therapy in patients who failed PDT and/or had recurrent neoplasia.
RESULTS
Fifty eight of 64 patients enrolled in the original trial were followed up including 31 patients treated with ALA PDT (17 patients with ≤6 cm, 14 patients with >6 cm segment of BE) and 27 treated with Photofrin PDT (14 patients with ≤6 cm, 13 patients with >6 cm BE). Initial success was achieved in 65% (20/31) ALA and 48% (13/27) Photofrin patients (p = .289). Thirty five percent patients (7/20) relapsed in ALA group and 54% (7/13) relapsed in Photofrin group (p = .472). At a median follow-up of 67 months, no significant difference was found in long-term complete reversal of intestinal metaplasia (CR-IM) and complete reversal of dysplasia (CR-D) between ALA and Photofrin groups (78% vs. 63%; p = .18; 90% vs. 76%; p = .26). Original length of BE did not alter long-term outcome. Four patients from each group progressed to invasive oesophageal adenocarcinoma. Initial success of ALA PDT was associated with significantly better likelihood of long-term remission (p = .03).
CONCLUSIONS
Initial response to PDT plays key role in long term outcome. RFA ± EMR have, however, become preferred minimally invasive ablative therapy for BE-related neoplasia due to poor efficacy of PDT.
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Additional Info
Disclosure statements are available on the authors' profiles:
Long-Term Outcomes of the Randomized Controlled Trial Comparing 5-Aminolaevulinic Acid and Photofrin Photodynamic Therapy for Barrett's Oesophagus Related Neoplasia
Scand. J. Gastroenterol. 2017 Nov 21;[EPub Ahead of Print], D Kohoutova, R Haidry, M Banks, MA Butt, J Dunn, S Thorpe, L LovatFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.